LPN1,2,3 and LEMP

Genetic Testing for neurological diseases  in Leonbergers

Order forms LPN, LPPN and LEMP tests Bern University
Formulaire de demande d'analyse LPN, LPPN et LEMP Bern
Untersuchungsantrag LPN, LPPN und LEMP Bern
Order form  LPN, LPPN and LEMP and info University of Minnesota

LEMP  and LPPN3 result of dogs that were allready tested for LPN can be  asked by email to cord.droegemueller@vetsuisse.unibe.ch Costs € 55 ,--
Click for the list of LPN1/2 LPPN 3 & LEMP test results

As off 30 October 2020 thge LPPN3 test is available.
Click for info

Laryngeal Paralysis - Polyneuropathy (LPN1, LPN2, & LPPN3)

LeonbergerLeonberger dogs may suffer from neuromuscular disease collectively termed Laryngeal Paralysis - Polyneuropathy (LPPN). Many LPPN affected dogs suffers from laryngeal paralysis; clinical signs include noisy breathing, a change in their bark, or even difficulty breathing due to involvement of the larynx and laryngeal folds in the throat. Additionally, dogs may show signs of slowly worsening exercise intolerance and develop gait abnormalities, such as an exaggerated hitched step, especially in the hind limbs; there is often wasting of the hind limb muscles as well. Eventually the disease may progress to the point where surgical intervention for laryngeal paralysis is required or the dog cannot support its own weight. Biopsies of nerve from affected dogs show degradation of the nerve fibers and loss of myelin, the insulating material that normally helps speed messages along nerves. Muscle biopsies show atrophy resulting from nerve loss. 

Dogs with LPPN may show only signs of laryngeal paralysis or only gait abnormalities at the onset of disease.

Research carried out at the University of Minnesota, the University of Bern, and the University of California, San Diego - Comparative Neuromuscular Laboratory indicates that polyneuropathy / laryngeal paralysis within the Leonberger breed is a group of several genetically distinct, but clinically similar diseases. We have mapped three major genetic risk loci and identified the causative mutations that we now term LPN1, LPN2, and LPPN3.

  • We have also identified LPPN3-D/D affected mixed breed dogs, and the mutation is present in several breeds.


For LEMP, LPN1 and LPPN3 we recommend avoiding matings that could produce LEMP-D/D (i.e. affected) dogs. Having only one LEMP-D/N parent, with a LEMP-N/N parent, will ensure that no LEMP-D/D offspring will be born.
For LPN2 we recommend avoiding matings that could produce LPN2-D/D and LPN2-D/N affected dogs.
 

Click for the LEMP manuscript

Vetsuisse Bern offers on its order form a genetic test for sand coat color.
Sand coat color is an officially allowed coat color for Leonbergers.
There is no need to exclude sand coloured Leonbergers from breeding.